3-(Diethylboryl)pyridine → HCID 18668632, compound

HRID 1059230Notes

Reaction equation

HRID 1059230 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]([C:13]2[N:14]=[CH:15][N:16]([C:18]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:17]=2)([OH:12])[CH:9]([CH3:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1.C(B(CC)[C:40]1[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=1)C>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:10][CH:9]([CH3:11])[C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:40]2[CH:41]=[N:42][CH:43]=[CH:44][CH:45]=2)[CH:3]=1)([C:13]1[N:14]=[CH:15][N:16]([C:18]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=1)[OH:12]

Participants

4

Reactant 2

HCID 6428513-(Diethylboryl)pyridineHCID 186685221-(3-bromophenyl)-(1-trityl-1H-imidazol-4-yl)-2-methyl-1-propanol

Product 1

HCID 18668632HCID 18668632, compoundYield 65.3%

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

By the reaction in the same manner as in Example 4-(ii) using 1-(3-bromophenyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)-1-propanol (1.01 g), diethyl(3-pyridyl)borane (0.497 g) and tetrakis(triphenylphosphine)palladium(0) (0.170 g), the title compound (0.657 g) was obtained as a pale-yellow amorphous powder.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-fb206d40d242421cade4ba1bd5208d82
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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