Pyridinium chloride → N-(6-{4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl}-2-pyridyl)acetamide

HRID 1059239Notes

Reaction equation

HRID 1059239 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[N:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][CH:37]=2)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[N:41]=[C:40]([NH:42][C:43](=[O:45])[CH3:44])[CH:39]=[CH:38][CH:37]=2)=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 18668520N-(6-(4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-2-pyridyl)acetamide

Product 1

HCID 178474125N-(6-{4-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]phenyl}-2-pyridyl)acetamideYield 59.4%

Procedure

By the reaction in the same manner as in Example 4-(iii) using N-(6-(4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-2-pyridyl)acetamide (1.48 g) and pyridine hydrochloride (520 mg), the title compound (520 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-f02e2ba5a4eb4f86a312bedca4d1fa87
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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