HRID1059242

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID84432

4-Amino-2-chloropyridine

C5H5ClN2

HCID253881

Sodium bromide

BrNa

结构：CC(C)C(O)(c1ccc(B(O)O)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668578

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(O)(c1ccc(-c2cc(N)ccn2)cc1)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1

HCID18668523

未命名化合物

收率 53.7%

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

PROCEDURE

实验过程

By the reaction in the same manner as in Example 33-(ii) using 4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenylboronic acid (5.78 g), 4-amino-2-chloropyridine (1.00 g), sodium bromide (810 mg) and tetrakis(triphenylphosphine)palladium(0) (0.190 g), the title compound (2.30 g) was obtained as a yellow amorphous powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6828dc973dda4c758883092eb0a5ade3
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06518257B1
来源说明: uspto-grants-2003_02

反应 SMILES

[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33](B(O)O)=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9]([C:11]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].[NH2:39][C:40]1[CH:45]=[CH:44][N:43]=[C:42](Cl)[CH:41]=1.[Br-].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[NH2:39][C:40]1[CH:45]=[CH:44][N:43]=[C:42]([C:33]2[CH:34]=[CH:35][C:30]([C:2]([C:6]3[N:7]=[CH:8][N:9]([C:11]([C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:12]4[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:10]=3)([OH:1])[CH:3]([CH3:5])[CH3:4])=[CH:31][CH:32]=2)[CH:41]=1