Pyridinium chloride → HCID 178485488, compound

HRID 1059252Notes

Reaction equation

HRID 1059252 reaction equation
[OH:1][C:2]([C:30]1[CH:35]=[CH:34][C:33]([C:36]2[CH:37]=[C:38]([CH:43]=[CH:44][N:45]=2)[C:39]([NH:41][CH3:42])=[O:40])=[CH:32][CH:31]=1)([C:6]1[N:7]=[CH:8][N:9](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:10]=1)[CH:3]([CH3:5])[CH3:4].Cl.N1C=CC=CC=1>>[OH:1][C:2]([C:30]1[CH:31]=[CH:32][C:33]([C:36]2[CH:37]=[C:38]([CH:43]=[CH:44][N:45]=2)[C:39]([NH:41][CH3:42])=[O:40])=[CH:34][CH:35]=1)([C:6]1[N:7]=[CH:8][NH:9][CH:10]=1)[CH:3]([CH3:4])[CH3:5]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 186686362-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-methylisonicotinamide

Product 1

HCID 178485488HCID 178485488, compoundYield 41.3%

Procedure

By the reaction in the same manner as in Example 4-(iii) using 2-{4-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]phenyl}-N-methylisonicotinamide (0.450 g) and pyridine hydrochloride (230 mg), the title compound (110 mg) was obtained as a colorless amorphous powder.

Workup

  1. customBy the reaction in the same manner as in Example

Sources & evidence

ORD record
ord-b77654e5bee5432b96d896f39b2a2788
Source dataset
uspto-grants-2003_02
Patent number
US06518257B1

Reaction notes

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