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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059253Generated: October 31, 2026

Sodium Carbonate → 4'-Fluoro-2-methoxy-1,1'-biphenyl

https://huagongshe.com/reaction/1059253

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium CarbonateHCID 10340—
Reactant2-BromoanisoleHCID 11358—
Reactant4-Fluorophenylboronic acidHCID 285645—
CatalystHCID 178418397HCID 178418397—
Product4'-Fluoro-2-methoxy-1,1'-biphenylHCID 1308954184.5%

Reaction Steps

By the reaction in the same manner as in Example 4-(ii) using 2-bromoanisole (8.91 g), 4-fluorophenylboronic acid (10.0 g), 2M aqueous sodium carbonate solution (47.6 ml) and tetrakis(triphenylphosphine)palladium(0) (2.20 g), the title compound (8.14 g) was obtained as colorless needle crystals.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06518257B1
Source datasetuspto-grants-2003_02
ORD IDord-a689a4a845844721b3654600a706b84d
Source noteuspto-grants-2003_02