Ethyl isocyanatoacetate → HCID 17174418, compound

HRID 1059342Notes

Reaction equation

HRID 1059342 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[N:15]([CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:16]=[O:17]>O1CCCC1>[CH2:8]([N:5]1[CH2:6][CH2:7][CH:2]([NH:1][C:16]([NH:15][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[O:17])[CH2:3][CH2:4]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 76283Ethyl isocyanatoacetateHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 17174418HCID 17174418, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 g of 4-amino-1-benzylpiperidine was dissolved in 15 ml of tetrahydrofuran. After adding 1.6 g of ethyl isocyanatoacetate, the resulting mixture was heated under reflux for 1 hour. Then the reaction mixture was concentrated under reduced pressure to thereby give 3.15 g of the title compound as white crystals.

Workup

  1. temperaturethe resulting mixture was heated
  2. temperatureunder reflux for 1 hour
  3. concentrationThen the reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5a8e6e30e95c45fb8c8fda1f77f13d39
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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