反应详情

温度

0 °C

To a solution of 2.2 g of 1-benzylisonipecotamide in 50 ml of tetrahydrofuran was added 1.58 g of lithium aluminum hydride at 0° C. and the resulting mixture was heated under reflux for 2 hours. Then the reaction mixture was cooled to 0° C. After adding water and a 10% aqueous solution of sodium hydroxide, the insoluble matters were filtered off. After distilling off the solvent under reduced pressure, 2.0 g of the title compound was obtained as a brown oily substance.

1. temperaturethe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. filtrationa 10% aqueous solution of sodium hydroxide, the insoluble matters were filtered off
4. distillationAfter distilling off the solvent under reduced pressure