反应详情

To 50 ml of a solution of 5 g of 8-(chloromethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine in dimethyl sulfoxide was added 0.92 g of sodium cyanide and the resulting mixture was reacted at 60° C. for 1 hour. After adding ethyl acetate, the organic layer was washed with water and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, 4.7 g of the title compound was obtained as a yellow solid.

1. customthe resulting mixture was reacted at 60° C. for 1 hour
2. washthe organic layer was washed with water
3. dry with materialdried over anhydrous magnesium sulfate
4. distillationAfter distilling off the solvent under reduced pressure