2-(4-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole → N,N-Dimethyl-2-[[4-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]hydroxymethyl]imidazole-1-sulfonamide

HRID 1059391Notes

Reaction equation

HRID 1059391 reaction equation
[CH3:1][N:2]([CH3:13])[S:3]([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH:11]=[O:12])(=[O:5])=[O:4].Br[C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:22][CH2:23][C:24]([CH3:27])([CH3:26])[N:25]=2)=[CH:17][CH:16]=1>>[CH3:1][N:2]([CH3:13])[S:3]([N:6]1[CH:10]=[CH:9][N:8]=[C:7]1[CH:11]([C:15]1[CH:20]=[CH:19][C:18]([C:21]2[O:22][CH2:23][C:24]([CH3:27])([CH3:26])[N:25]=2)=[CH:17][CH:16]=1)[OH:12])(=[O:4])=[O:5]

Participants

3

Reactant 2

HCID 4033952-(4-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazoleHCID 102622902-formyl-N,N-dimethyl-1H-imidazole-1-sulfonamide

Product 1

HCID 18670283N,N-Dimethyl-2-[[4-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]hydroxymethyl]imidazole-1-sulfonamideYield 40.3%

Procedure

Similar to Production Example 164, 4.54 g of N,N-dimethyl-2-formylimidazole-1-sulfonamide was treated with 7.0 g of 2-(4-bromophenyl)-4,4-dimethyl-2-oxazoline to thereby give 3.41 g of the title compound.

Sources & evidence

ORD record
ord-ae3128d34ff3454195302e08aea84a3f
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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