Hydrochloric Acid → HCID 18670461, compound

HRID 1059394Notes

Reaction equation

HRID 1059394 reaction equation
C(O)C.[N:4]1[C:12]([C:13](=[O:15])[CH3:14])=[C:11]2[C:7]([N:8]=[CH:9][NH:10]2)=[N:6][CH:5]=1.[BH4-].[Na+].Cl>O>[N:4]1[C:12]([CH:13]([OH:15])[CH3:14])=[C:11]2[C:7]([N:8]=[CH:9][NH:10]2)=[N:6][CH:5]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 4311764Sodium borohydrideHCID 21905845HCID 21905845, compound

Product 1

HCID 18670461HCID 18670461, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To an ethanol solution (80 ml) of 0.70 g of (purin-6-yl)ethanone was added 0.70 g of sodium borohydride and the resulting mixture was stirred at room temperature for 4 hours. The excessive reagent was decomposed by adding water and 4 N hydrochloric acid and distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluted by dichloromethane/methanol) to thereby give 0.57 g of the title compound as a white solid.

Workup

  1. distillationdistilled off under reduced pressure
  2. customThe residue was purified by silica gel column chromatography (eluted by dichloromethane/methanol)

Sources & evidence

ORD record
ord-b2e0c75d92944fbf9ae3a255092f23d6
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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