Ammonia → HCID 18670425, compound

HRID 1059398Notes

Reaction equation

HRID 1059398 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][N:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]3[S:21][C:20]4[N:22]=[CH:23][CH:24]=[N:25][C:19]=4[N:18]([CH2:26][O:27][CH3:28])[C:17]=3[CH:29]=2)[C:10]=1[CH3:11])=O)C.[NH3:30]>O1CCCC1>[CH3:28][O:27][CH2:26][N:18]1[C:17]2[CH:29]=[C:13]([CH2:12][N:9]3[C:10]([CH3:11])=[C:6]([C:4]([NH2:30])=[O:3])[N:7]=[CH:8]3)[CH:14]=[CH:15][C:16]=2[S:21][C:20]2[N:22]=[CH:23][CH:24]=[N:25][C:19]1=2

Participants

4

Reactant 2

HCID 222AmmoniaHCID 23564784HCID 23564784, compound

Product 1

HCID 18670425HCID 18670425, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of 0.7 g of ethyl[1-[10-(methoxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl]-5-methylimidazol-4-yl]carboxylate in tetrahydrofuran (10 ml) was added 50 ml of aqueous ammonia. After sealing, the resulting mixture was heated to 100° C. for 24 hours.

Sources & evidence

ORD record
ord-751015cb15ba4331ba1002d83a80c612
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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