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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059415Generated: October 30, 2026

Hydroxylamine → (10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole

https://huagongshe.com/reaction/1059415

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydroxylamineHCID 787—
ReactantHCID 18670109HCID 18670109—
Reactant(10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazoleHCID 69885066—
Product(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazoleHCID 69884086—

Reaction Steps

Similar to Example 1223, 1-(10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-1,3-butanedione was treated with hydroxylamine to thereby give (10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole. Further, this product was treated by the same method as the one of Example 9 to thereby give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06518423B1
Source datasetuspto-grants-2003_02
ORD IDord-101a0798e6914ec0bce36b6f47aa9986
Source noteuspto-grants-2003_02