Hydroxylamine → (10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole

HRID 1059415Notes

Reaction equation

HRID 1059415 reaction equation
COCN1C2C=C(C(=O)CC(=O)C)C=CC=2SC2N=CC=NC1=2.NO.COC[N:29]1[C:34]2[CH:35]=[C:36]([C:39]3[C:40]([CH3:44])=[N:41][O:42][CH:43]=3)[CH:37]=[CH:38][C:33]=2[S:32][C:31]2[N:45]=[CH:46][CH:47]=[N:48][C:30]1=2>>[N:48]1[C:30]2[NH:29][C:34]3[CH:35]=[C:36]([C:39]4[C:40]([CH3:44])=[N:41][O:42][CH:43]=4)[CH:37]=[CH:38][C:33]=3[S:32][C:31]=2[N:45]=[CH:46][CH:47]=1

Participants

4

Reactant 3

HCID 787HydroxylamineHCID 18670109HCID 18670109, compoundHCID 69885066(10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole

Product 1

HCID 69884086(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole

Procedure

Similar to Example 1223, 1-(10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-1,3-butanedione was treated with hydroxylamine to thereby give (10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)-3-methylisoxazole. Further, this product was treated by the same method as the one of Example 9 to thereby give the title compound.

Workup

  1. additionFurther, this product was treated by the same method as the one of Example 9

Sources & evidence

ORD record
ord-101a0798e6914ec0bce36b6f47aa9986
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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