HCID 178496766, compound → HCID 178420742, compound

HRID 1059419Notes

Reaction equation

HRID 1059419 reaction equation
[NH:1]1[C:5]([C:6]2[CH:7]=[CH:8][C:9]3[S:14][C:13]4[N:15]=[CH:16][CH:17]=[N:18][C:12]=4[N:11](COC)[C:10]=3[CH:22]=2)=[N:4][N:3]=[N:2]1>C(O)(=O)C>[NH:1]1[C:5]([C:6]2[CH:7]=[CH:8][C:9]3[S:14][C:13]4[N:15]=[CH:16][CH:17]=[N:18][C:12]=4[NH:11][C:10]=3[CH:22]=2)=[N:4][N:3]=[N:2]1

Participants

3

Reactant 1

HCID 178496766HCID 178496766, compound

Product 1

HCID 178420742HCID 178420742, compoundYield 52.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

40 mg of 8-(tetrazol-5-yl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was heated 5 ml of glacial acetic acid to 60° C. for 30 minutes. After the completion of the reaction, silica gel was added thereto. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol/acetic acid) to thereby give 18 mg of the title compound as yellow crystals.

Workup

  1. customAfter the completion of the reaction, silica gel
  2. additionwas added
  3. distillationAfter distilling off the solvent under reduced pressure
  4. customthe residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol/acetic acid)

Sources & evidence

ORD record
ord-7aaa71281ce54571bcecb51743f83b31
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

Loading…