HCID 178496766, compound → HCID 178420742, compound

Participants

Reaction Steps

40 mg of 8-(tetrazol-5-yl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was heated 5 ml of glacial acetic acid to 60° C. for 30 minutes. After the completion of the reaction, silica gel was added thereto. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluted with dichloromethane/methanol/acetic acid) to thereby give 18 mg of the title compound as yellow crystals.

Provenance & Evidence