Hydrochloric Acid → HCID 18670241, compound

Participants

Reaction Steps

To a solution of 5.0 g of 8-(aminomethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine in a mixture of dry methanol (5 ml)/ethyl acetate (30 ml) was added 10 ml of a solution of 22 g of hydrogen chloride in 500 ml of ethyl acetate and the resulting mixture was subjected to ultrasonication. To the crystals thus precipitated was added diethyl ether followed by filtration. Thus, the title compound was obtained as orange crystals almost quantitatively.

Provenance & Evidence