Hydrochloric Acid → HCID 18670241, compound

HRID 1059425Notes

Reaction equation

HRID 1059425 reaction equation
[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[S:11][C:10]3[N:12]=[CH:13][CH:14]=[N:15][C:9]=3[NH:8][C:7]=2[CH:16]=1.CO.[ClH:19]>C(OCC)(=O)C>[ClH:19].[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[S:11][C:10]3[N:12]=[CH:13][CH:14]=[N:15][C:9]=3[NH:8][C:7]=2[CH:16]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18670209HCID 18670209, compound

Product 1

HCID 18670241HCID 18670241, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 5.0 g of 8-(aminomethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine in a mixture of dry methanol (5 ml)/ethyl acetate (30 ml) was added 10 ml of a solution of 22 g of hydrogen chloride in 500 ml of ethyl acetate and the resulting mixture was subjected to ultrasonication. To the crystals thus precipitated was added diethyl ether followed by filtration. Thus, the title compound was obtained as orange crystals almost quantitatively.

Workup

  1. customthe resulting mixture was subjected to ultrasonication
  2. customTo the crystals thus precipitated
  3. additionwas added diethyl ether
  4. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-d707e22b42fe4f5185f3bc7195174418
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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