Acetic Anhydride → HCID 18670544, compound

HRID 1059432Notes

Reaction equation

HRID 1059432 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10][C:9]3[N:11]=[CH:12][CH:13]=[N:14][C:8]=3[N:7]([CH2:15][O:16][CH3:17])[C:6]=2[CH:18]=1.[C:19](OC(=O)C)(=[O:21])[CH3:20]>C(OCC)(=O)C>[CH3:17][O:16][CH2:15][N:7]1[C:6]2[CH:18]=[C:2]([NH:1][C:19](=[O:21])[CH3:20])[CH:3]=[CH:4][C:5]=2[S:10][C:9]2[N:11]=[CH:12][CH:13]=[N:14][C:8]1=2

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18670314HCID 18670314, compound

Product 1

HCID 18670544HCID 18670544, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

200 mg of 8-amino-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was suspended in 10 ml of ethyl acetate. After adding 1 ml of acetic anhydride, the reaction mixture was subjected to ultrasonication. The crystals thus precipitated were filtered and washed with diethyl ether to thereby give 206 mg of the title compound as yellow crystals.

Workup

  1. customthe reaction mixture was subjected to ultrasonication
  2. customThe crystals thus precipitated
  3. filtrationwere filtered
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-5748947c6b45446298a37faf9a4dcf57
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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