Tetrabutylammonium Fluoride → HCID 86592279, compound

HRID 1059443Notes

Reaction equation

HRID 1059443 reaction equation
I[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[S:20][C:19]3[N:21]=[CH:22][CH:23]=[N:24][C:18]=3[N:17](COC)[C:16]=2[CH:28]=1.IC1N=CN=C2C=1N=CN2CC1C=CC2SC3N=CC=NC=3NC=2C=1.[O:54]([CH2:62][C:63]([CH2:67][O:68][Si](C(C)(C)C)(C)C)([OH:66])[C:64]#[CH:65])[Si](C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>>[N:24]1[C:18]2[NH:17][C:16]3[CH:28]=[C:12]([CH2:11][N:6]4[CH:5]=[N:4][C:3]5[C:7]4=[N:8][CH:9]=[N:10][C:2]=5[CH:62]([OH:54])[C:63]([CH2:67][OH:68])([OH:66])[C:64]#[CH:65])[CH:13]=[CH:14][C:15]=3[S:20][C:19]=2[N:21]=[CH:22][CH:23]=1

Participants

5

Reactant 4

HCID 2724141Tetrabutylammonium FluorideHCID 18670284HCID 18670284, compoundHCID 18670338HCID 18670338, compoundHCID 18670340HCID 18670340, compound

Product 1

HCID 86592279HCID 86592279, compound

Procedure

8-(6-Iodopurin-9-ylmethyl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was treated by the same method as the one of Example 9 to thereby give 8-(6-iodopurin-9-ylmethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine. Next, this product was treated with bis(tert-butyldimethylsiloxymethyl)-2-propyn-1-ol by the same method as the one of Example 1417. The compound thus obtained was further treated with tetrabutylammonium fluoride in accordance with the method of Example 1386-3 to thereby give the title compound.

Workup

  1. customThe compound thus obtained

Sources & evidence

ORD record
ord-a66848b369274a7bae60810938797504
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

Loading…