Triethylamine → 6-(1-Chloroethyl)-5-iodo-4-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidine

HRID 1059692Notes

Reaction equation

HRID 1059692 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][NH2:12])=[CH:6][CH:5]=1.C(N(CC)CC)C.Cl[C:23]1[C:28]([I:29])=[C:27]([CH:30]([Cl:32])[CH3:31])[N:26]=[CH:25][N:24]=1>C1(C)C=CC=CC=1>[Cl:32][CH:30]([C:27]1[N:26]=[CH:25][N:24]=[C:23]([NH:12][CH2:11][CH2:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:13])([F:14])[F:1])=[CH:9][CH:8]=2)[C:28]=1[I:29])[CH3:31]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 106320402-[4-(Trifluoromethoxy)phenyl]ethan-1-amineHCID 154522994-Chloro-6-(1-chloroethyl)-5-iodopyrimidine

Product 1

HCID 154523086-(1-Chloroethyl)-5-iodo-4-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
60 °C

Procedure

In toluene (50 ml) were dissolved 2-(4-trifluoromethoxyphenyl)ethylamine (1.0 g) and triethylamine (1.0 g), then, 4-chloro-6-(1-chloroethyl)-5-iodopyrimidine (1.5 g) was added to the solution, and the mixture was heated at about 60° C. for 3 hours while stirring.

Sources & evidence

ORD record
ord-0178704ee76348589bb9687d0c765fd9
Source dataset
uspto-grants-2003_02
Patent number
US06521627B1

Reaction notes

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