反应详情

Intermediate 54 (6 g) obtained above was added to a 10% hydrogen chloride solution in methanol (50 ml) and stirred under reflux by heating for 1.5 hours. The solvent was evaporated under reduced pressure, and the residue was dissolved in a mixed solvent of dichloromethane and ethanol, added with saturated aqueous potassium carbonate and vigorously shaken. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain the title compound (4.9 g).

1. temperatureunder reflux
2. temperatureby heating for 1.5 hours
3. customThe solvent was evaporated under reduced pressure
4. dissolutionthe residue was dissolved in a mixed solvent of dichloromethane and ethanol
5. additionadded with saturated aqueous potassium carbonate
6. stirringvigorously shaken
7. dry with materialThe organic layer was dried over anhydrous sodium sulfate
8. customthe solvent was evaporated under reduced pressure