反应详情

温度

40 °C

A mixture of 2-(tert-butyloxycarbonyl)-5-cyano-2,3-dihydro-1H-isoindole (7.6 g) and trifluoroacetic acid (20 ml) in dichloromethane (200 ml) was heated at 40° C. for 0.5 h, then cooled and evaporated in vacuo and the residue partitioned between dichloromethane and 2M sodium hydroxide. The aqueous phase was re-extracted with dichloromethane and the combined organics dried and evaporated to give the title compound as a pink solid (4.24 g, 94%).

1. temperaturecooled
2. customevaporated in vacuo
3. customthe residue partitioned between dichloromethane and 2M sodium hydroxide
4. extractionThe aqueous phase was re-extracted with dichloromethane
5. customthe combined organics dried
6. customevaporated