反应详情

A solution of indoline (5.0 g) and 98% formic acid (3.0 g) in toluene (17 mL) was heated at reflux for 6 hours with a Dean-Stark trap, cooled, washed with water and concentrated. The resulting dark brown solid was dissolved in methanol, concentrated to a fraction of its original volume, treated with 1:1 diethyl ether/hexane, and concentrated dryness to provide 5.5 g of the desired product.

1. temperatureat reflux for 6 hours with a Dean-Stark trap
2. temperaturecooled
3. washwashed with water
4. concentrationconcentrated
5. dissolutionThe resulting dark brown solid was dissolved in methanol
6. concentrationconcentrated to a fraction of its original volume
7. additiontreated with 1:1 diethyl ether/hexane
8. concentrationconcentrated dryness