HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → tert-butyl N-(5-amino-2-methoxyphenyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Tert-butyl 2-methoxy-5-nitrophenylcarbamate | HCID 45790233 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | tert-butyl N-(5-amino-2-methoxyphenyl)carbamate | HCID 22344747 | — |
Reaction Steps
A solution of Example 28A in 1:1 THF:methanol (40 mL) was treated with 10% palladium on carbon (800 mg), stirred under hydrogen (1 atm) for one hour, filtered through diatomaceous earth (Celite®), and concentrated to provide the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521658B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-8f1b2fd489d34d4d93b6abb5838382f3 |
| Source note | uspto-grants-2003_02 |