Benzoyl isothiocyanate → HCID 18667648, compound

HRID 1059874Notes

Reaction equation

HRID 1059874 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=2)=[C:5]([CH3:7])[N:6]=1.[C:15]([N:23]=[C:24]=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CC(C)=O>[CH3:7][C:5]1[N:6]=[C:2]([NH:1][C:24]([NH:23][C:15](=[O:22])[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[S:25])[S:3][C:4]=1[C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 186309852-Amino-4-methyl-5-(4-methylpyridin-2-yl)-thiazole

Product 1

HCID 18667648HCID 18667648, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

To a suspension of 2-amino-4-methyl-5-(4-methylpyridin-2-yl)-thiazole (615 mg) in acetone (5 ml) was added a solution of benzoyl isothiocyanate (0.443 ml) in acetone (5 ml) dropwise, and the mixture was heated under reflux for 3 hours. After cooling, the resulting precipitate was collected by filtration and dried to give N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-N′-benzoylthiourea (490 mg).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperatureAfter cooling
  4. filtrationthe resulting precipitate was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-37f140b1b1b0465180a422806f77fa04
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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