反应详情

To a suspension of 2-amino-4-methyl-5-(4-methylpyridin-2-yl)-thiazole (615 mg) in acetone (5 ml) was added a solution of benzoyl isothiocyanate (0.443 ml) in acetone (5 ml) dropwise, and the mixture was heated under reflux for 3 hours. After cooling, the resulting precipitate was collected by filtration and dried to give N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-N′-benzoylthiourea (490 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. temperatureAfter cooling
4. filtrationthe resulting precipitate was collected by filtration
5. customdried