Hydrazine hydrate (1:1) → HCID 178428485, compound

HRID 1059877Notes

Reaction equation

HRID 1059877 reaction equation
Cl.Cl.[CH3:3][C:4]1[N:5]=[C:6]([NH:16][C:17](=[NH:21])SCC)[S:7][C:8]=1[C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][N:10]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:3][C:4]1[N:5]=[C:6]([NH:16][C:17]([NH:23][NH2:24])=[NH:21])[S:7][C:8]=1[C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178477487HCID 178477487, compound

Product 1

HCID 178428485HCID 178428485, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a suspension of N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-S-ethylisothiourea dihydrochloride (36.5 mg) in ethanol (0.5 ml) was added hydrazine hydrate (50 mg). The mixture was stirred at 80° C. for 1 hour and cooled to ambient temperature. The precipitate was collected by filtration, washed with ethanol, water and diisopropyl ether to give N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-N′-aminoguanidine (11 mg).

Workup

  1. temperaturecooled to ambient temperature
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with ethanol, water and diisopropyl ether

Sources & evidence

ORD record
ord-3347caacca1f4368b9ebd058e163b8f8
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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