反应详情

温度

80 °C

To a suspension of N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-S-ethylisothiourea dihydrochloride (36.5 mg) in ethanol (0.5 ml) was added hydrazine hydrate (50 mg). The mixture was stirred at 80° C. for 1 hour and cooled to ambient temperature. The precipitate was collected by filtration, washed with ethanol, water and diisopropyl ether to give N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-N′-aminoguanidine (11 mg).

1. temperaturecooled to ambient temperature
2. filtrationThe precipitate was collected by filtration
3. washwashed with ethanol, water and diisopropyl ether