Dimethylformamide dimethyl acetal → HCID 57286424, compound

HRID 1059884Notes

Reaction equation

HRID 1059884 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=2)=[C:5]([CH3:7])[N:6]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:17][N:18]([CH3:20])[CH:19]=[N:1][C:2]1[S:3][C:4]([C:8]2[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=2)=[C:5]([CH3:7])[N:6]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 186309852-Amino-4-methyl-5-(4-methylpyridin-2-yl)-thiazole

Product 1

HCID 57286424HCID 57286424, compound

Procedure

A solution of 2-amino-4-methyl-5-(4-methylpyridin-2-yl)thiazole (300 mg) in N,N-dimethylformamide dimethyl acetal (1.5 ml) was stirred at ambient temperature for 14 hours and evaporated under reduced pressure. The residue was triturated with 2-propanol (1 ml) and diisopropyl ether, and the solid was collected by filtration, washed with diisopropyl ether and dried under reduced pressure to give N,N-dimethyl-N′-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-formamidine (268 mg).

Workup

  1. customevaporated under reduced pressure
  2. customThe residue was triturated with 2-propanol (1 ml) and diisopropyl ether
  3. filtrationthe solid was collected by filtration
  4. washwashed with diisopropyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-e5adbd4e580a4e6488d21d6e37e19ff7
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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