Hydrochloric Acid → HCID 178428517, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of N-(5-(acetylamino-(4-methylpyridin-2-yl)-methyl)-4-methylthiazol-2-yl)guanidine (176 mg) in methanol (8.8 ml) was added hydrochloric acid (6 N, 4.6 ml), and the mixture was stirred at 90° C. for 4 hours. The mixture was evaporated under reduced pressure. The residue was recrystallized from ethanol to give N-(5-(amino-(4-methylpyridin-2-yl)methyl)-4-methylthiazol-2-yl)-guanidine trihydrochloride (141 mg).

Provenance & Evidence