Hydrochloric Acid → HCID 178428517, compound

HRID 1059890Notes

Reaction equation

HRID 1059890 reaction equation
C([NH:4][CH:5]([C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][N:17]=1)[C:6]1[S:10][C:9]([NH:11][C:12]([NH2:14])=[NH:13])=[N:8][C:7]=1[CH3:15])(=O)C.[ClH:23]>CO>[ClH:23].[ClH:23].[ClH:23].[NH2:4][CH:5]([C:16]1[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][N:17]=1)[C:6]1[S:10][C:9]([NH:11][C:12]([NH2:14])=[NH:13])=[N:8][C:7]=1[CH3:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178474535HCID 178474535, compound

Product 1

HCID 178428517HCID 178428517, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
90 °C

Procedure

To a suspension of N-(5-(acetylamino-(4-methylpyridin-2-yl)-methyl)-4-methylthiazol-2-yl)guanidine (176 mg) in methanol (8.8 ml) was added hydrochloric acid (6 N, 4.6 ml), and the mixture was stirred at 90° C. for 4 hours. The mixture was evaporated under reduced pressure. The residue was recrystallized from ethanol to give N-(5-(amino-(4-methylpyridin-2-yl)methyl)-4-methylthiazol-2-yl)-guanidine trihydrochloride (141 mg).

Workup

  1. customThe mixture was evaporated under reduced pressure
  2. customThe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-ee3b5e40542447aeaa1437f1f748daad
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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