反应详情

To a solution of 1-(4-methylpyridin-2-yl)-3-(tert-butoxycarbonylamino)pyrrolidine (0.72 g) in dichloromethane (5 ml) was added a solution of hydrogen chloride in 1,4-dioxane (5 ml), and the resultant mixture was stirred at ambient temperature for 3 hours and evaporated under reduced pressure. To the residue was added 1N aqueous sodium hydroxide (30 ml) and extracted with ethyl acetate-tetrahydrofuran (2:1) three times. The combined organic layer was washed with brine, dried over sodium sulfate and evaporated under reduced pressure to give 3-amino-1-(4-methylpyridin-2-yl)pyrrolidine (409 mg).

1. customevaporated under reduced pressure
2. additionTo the residue was added 1N aqueous sodium hydroxide (30 ml)
3. extractionextracted with ethyl acetate-tetrahydrofuran (2:1) three times
4. washThe combined organic layer was washed with brine
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure