Hydrochloric Acid → HCID 178464610, compound

HRID 1059898Notes

Reaction equation

HRID 1059898 reaction equation
C(OC([NH:8][C:9]([NH:23][CH2:24][CH3:25])=[N:10][CH:11]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][N:17]=2)[CH2:12]1)=O)(C)(C)C.[ClH:26]>C(O)C.O1CCOCC1>[ClH:26].[ClH:26].[CH2:24]([NH:23][C:9]([NH:10][CH:11]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][N:17]=2)[CH2:12]1)=[NH:8])[CH3:25]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178464555N-(tert-butoxycarbonyl)-N'-ethyl-N''-(1-(4-methylpyridin-2-yl)pyrrolidin-3-yl)guanidine

Product 1

HCID 178464610HCID 178464610, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N-(tert-butoxycarbonyl)-N′-ethyl-N″-(1-(4-methylpyridin-2-yl)pyrrolidin-3-yl)guanidine (200 mg) in ethanol (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 3 ml), and the mixture was stirred at ambient temperature for 6 hours. The solvent was evaporated under reduced pressure. To the residue was added 10% ethanol in ethyl acetate (50 ml), and the resultant precipitate was collected by filtration and dried under reduced pressure to give N-ethyl-N′-(1-(4-methylpyridin-2-yl)pyrrolidin-3-yl)guanidine dihydrochloride (120 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 10% ethanol in ethyl acetate (50 ml)
  3. filtrationthe resultant precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-763b3b12bb1a44a98e5de820e9bebd70
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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