Dimethylformamide dimethyl acetal → 3-Dimethylamino-1-(4-methyl-2-pyridyl)-2-propen-1-one

Participants

Reaction Steps

A suspension of 2-acetyl-4-methylpyridine (0.65 g) in N,N-dimethylformamide dimethyl acetal (4 ml) was refluxed for 10 hours and evaporated under reduced pressure. The residue was triturated with diisopropyl ether, filtered and dried under reduced pressure to give 3-dimethylamino-1-(4-methylpyridin-2-yl)prop-2-en-1-one (777 mg).

Provenance & Evidence