反应详情

A suspension of 2-acetyl-4-methylpyridine (0.65 g) in N,N-dimethylformamide dimethyl acetal (4 ml) was refluxed for 10 hours and evaporated under reduced pressure. The residue was triturated with diisopropyl ether, filtered and dried under reduced pressure to give 3-dimethylamino-1-(4-methylpyridin-2-yl)prop-2-en-1-one (777 mg).

1. temperaturewas refluxed for 10 hours
2. customevaporated under reduced pressure
3. customThe residue was triturated with diisopropyl ether
4. filtrationfiltered
5. customdried under reduced pressure