Ethylamine → HCID 178464611, compound

HRID 1059901Notes

Reaction equation

HRID 1059901 reaction equation
[CH2:1]([NH2:3])[CH3:2].[CH3:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]#[N:19])[N:12]=2)[CH:6]=1>C(O)C>[CH2:1]([NH:3][C:18]([NH:17][C:13]1[N:12]=[C:11]([C:7]2[CH:6]=[C:5]([CH3:4])[CH:10]=[CH:9][N:8]=2)[CH:16]=[CH:15][N:14]=1)=[NH:19])[CH3:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 18667558N-(4-(4-methylpyridin-2-yl)pyrimidin-2-yl)cyanamide

Product 1

HCID 178464611HCID 178464611, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethylamine in ethanol (20 w/w %, 5 ml) was added N-(4-(4-methylpyridin-2-yl)pyrimidin-2-yl)cyanamide (150 mg). The mixture was heated in a steel autoclave at 120° C. for 4.5 hours. After cooling, the solvent was evaporated under reduced pressure. To the residue was added 2-propanol, and the resultant precipitate was collected by filtration and dried under reduced pressure to give N-ethyl-N′-(4-(4-methylpyridin-2-yl)pyrimidin-2-yl)guanidine (50 mg).

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated under reduced pressure
  3. additionTo the residue was added 2-propanol
  4. filtrationthe resultant precipitate was collected by filtration
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-c244f5181e1141439ab0229a8f726c2f
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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