Ethylamine → HCID 178464611, compound

Participants

Reaction Steps

To a solution of ethylamine in ethanol (20 w/w %, 5 ml) was added N-(4-(4-methylpyridin-2-yl)pyrimidin-2-yl)cyanamide (150 mg). The mixture was heated in a steel autoclave at 120° C. for 4.5 hours. After cooling, the solvent was evaporated under reduced pressure. To the residue was added 2-propanol, and the resultant precipitate was collected by filtration and dried under reduced pressure to give N-ethyl-N′-(4-(4-methylpyridin-2-yl)pyrimidin-2-yl)guanidine (50 mg).

Provenance & Evidence