Hydrochloric Acid → HCID 178428563, compound

HRID 1059903Notes

Reaction equation

HRID 1059903 reaction equation
C(OC([NH:8][C:9]([NH:23]C(OC(C)(C)C)=O)=[N:10][C:11]1[N:12]=[CH:13][N:14]([C:16]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][N:17]=2)[CH:15]=1)=O)(C)(C)C.[ClH:31]>ClCCl.O1CCOCC1>[ClH:31].[ClH:31].[CH3:22][C:20]1[CH:19]=[CH:18][N:17]=[C:16]([N:14]2[CH:15]=[C:11]([NH:10][C:9]([NH2:23])=[NH:8])[N:12]=[CH:13]2)[CH:21]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 135710949HCID 135710949, compound

Product 1

HCID 178428563HCID 178428563, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(1-(4-methylpyridin-2-yl)imidazol-4-yl)guanidine (200 mg) in dichloromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at ambient temperature for 23 hours. The solvent was evaporated under reduced pressure. To the residue was added 2-propanol, and the resultant precipitate was collected by filtration and dried under reduced pressure to give (1-(4-methylpyridin-2-yl)imidazol-4-yl)guanidine dihydrochloride (94 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 2-propanol
  3. filtrationthe resultant precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-316edfb1425649c288a51bc8b9c63c8c
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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