Hydrochloric Acid → HCID 178478788, compound

HRID 1059917Notes

Reaction equation

HRID 1059917 reaction equation
C(OC([NH:8][C:9]([NH:26]C(OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][CH:20]=[CH:19][N:18]=2)[CH:12]=1)=O)(C)(C)C.[ClH:34]>ClCCl.O1CCOCC1>[ClH:34].[ClH:34].[N+:23]([C:22]1[C:17]([C:13]2[CH:12]=[C:11]([NH:10][C:9]([NH2:26])=[NH:8])[CH:16]=[CH:15][CH:14]=2)=[N:18][CH:19]=[CH:20][CH:21]=1)([O-:25])=[O:24]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 135706156HCID 135706156, compound

Product 1

HCID 178478788HCID 178478788, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(3-(3-nitropyridin-2-yl)phenyl)guanidine (200 mg) in dichloromethane (2 ml) was added 4N hydrogen chloride in 1,4-dioxane (2 ml), and the mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (100 ml), and the.precipitate was collected by filtration and dried under reduced pressure to give 3-(3-nitropyridin-2-yl)phenylguanidine dihydrochloride (127 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 5% ethanol in ethyl acetate (100 ml)
  3. filtrationthe.precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-eab142b5d9e64c08bf064986615f00f9
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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