Hydrochloric Acid → HCID 178466935, compound

HRID 1059935Notes

Reaction equation

HRID 1059935 reaction equation
C(OC([NH:8][C:9]([NH:26]C(OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]2[CH:22]=[C:21]([O:23][CH2:24][CH3:25])[CH:20]=[CH:19][N:18]=2)[CH:12]=1)=O)(C)(C)C.[ClH:34]>ClCCl.O1CCOCC1>[ClH:34].[ClH:34].[CH2:24]([O:23][C:21]1[CH:20]=[CH:19][N:18]=[C:17]([C:13]2[CH:12]=[C:11]([NH:10][C:9]([NH2:26])=[NH:8])[CH:16]=[CH:15][CH:14]=2)[CH:22]=1)[CH3:25]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 136134137N,N'-bis(tert-butoxycarbonyl)-N''-(3-(4-ethoxypyridin-2-yl)phenyl)guanidine

Product 1

HCID 178466935HCID 178466935, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N,N′-bis (tert-butoxycarbonyl)-N″-(3-(4-ethoxypyridin-2-yl)phenyl)guanidine (200 mg) in dichioromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure. To the residue was added 10% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 3-(4-ethoxypyridin-2-yl)phenylguanidine dihydrochloride (126 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 10% ethanol in ethyl acetate (50 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-59816dafcd0147469b08347bb4cbe2b4
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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