反应详情

温度

80 °C

To a suspension of 2-bromo-4-methoxypyridine (1.88 g), 2-methylphenylboronic acid (1.77 g) and tetrakis(triphenylphosphine)-palladium (578 mg) in 1,2-dimethoxyethane (30 ml) was added 2M aqueous solution of sodium carbonate (13 ml). The mixture was stirred at 80° C. for 7 hours under a nitrogen atmosphere, then cooled to room temperature and diluted with ethyl acetate. The organic layer was separated, washed with water and brine and dried over sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by column chromatography (silica gel 50 g, 25% ethyl acetate in n-hexane) to give 2-(4-methoxypyridin-2-yl)toluene (1.98 g).

1. temperaturecooled to room temperature
2. customThe organic layer was separated
3. washwashed with water and brine
4. dry with materialdried over sodium sulfate
5. customThe solvent was evaporated under reduced pressure
6. customThe residue was purified by column chromatography (silica gel 50 g, 25% ethyl acetate in n-hexane)