Hydrochloric Acid → HCID 178493123, compound

Participants

Reaction Steps

To a solution of 2,4-bis(N,N′-bis(tert-butoxycarbonyl)guanidino)-6-(4-methoxypyridin-2-yl)toluene (0.15 g) in dichloromethane (3 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 3 ml), and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 2,4-diguanidino-6-(4-methoxypyridin-2-yl)toluene trihydrochloride (85 mg).

Provenance & Evidence