Hydrochloric Acid → HCID 178493123, compound

HRID 1059964Notes

Reaction equation

HRID 1059964 reaction equation
C(OC([N:8]([C:19]1[CH:24]=[C:23]([N:25](C(OC(C)(C)C)=O)[C:26]([NH2:35])=[N:27]C(OC(C)(C)C)=O)[CH:22]=[C:21]([C:43]2[CH:48]=[C:47]([O:49][CH3:50])[CH:46]=[CH:45][N:44]=2)[C:20]=1[CH3:51])[C:9]([NH2:18])=[N:10]C(OC(C)(C)C)=O)=O)(C)(C)C.[ClH:52]>ClCCl.O1CCOCC1>[ClH:52].[ClH:52].[ClH:52].[NH:8]([C:19]1[CH:24]=[C:23]([NH:25][C:26]([NH2:35])=[NH:27])[CH:22]=[C:21]([C:43]2[CH:48]=[C:47]([O:49][CH3:50])[CH:46]=[CH:45][N:44]=2)[C:20]=1[CH3:51])[C:9]([NH2:18])=[NH:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57210878HCID 57210878, compound

Product 1

HCID 178493123HCID 178493123, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2,4-bis(N,N′-bis(tert-butoxycarbonyl)guanidino)-6-(4-methoxypyridin-2-yl)toluene (0.15 g) in dichloromethane (3 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 3 ml), and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 2,4-diguanidino-6-(4-methoxypyridin-2-yl)toluene trihydrochloride (85 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 5% ethanol in ethyl acetate (50 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-5b7b9cf746554f7483f1ae1b1ec8ac6a
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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