Hydrochloric Acid → HCID 178493116, compound

HRID 1059977Notes

Reaction equation

HRID 1059977 reaction equation
C(OC([NH:8][C:9]([NH:26]C(OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[C:15]([C:17]2[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][N:18]=2)[CH:14]=[CH:13][C:12]=1[CH3:25])=O)(C)(C)C.[ClH:34]>ClCCl.O1CCOCC1>[ClH:34].[ClH:34].[CH3:24][O:23][C:21]1[CH:20]=[CH:19][N:18]=[C:17]([C:15]2[CH:14]=[CH:13][C:12]([CH3:25])=[C:11]([NH:10][C:9]([NH2:26])=[NH:8])[CH:16]=2)[CH:22]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 135710951HCID 135710951, compound

Product 1

HCID 178493116HCID 178493116, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(5-(4-methoxypyridin-2-yl)-2-methylphenyl)guanidine (200 mg) in dichloromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at room temperature for 18 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (100 ml), and the precipitate was collected by filtration and dried under reduced pressure to give (5-(4-methoxypyridin-2-yl)-2-methylphenyl)-guanidine dihydrochloride (127 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 5% ethanol in ethyl acetate (100 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-f50fd3fd060a434b87695794a1771eda
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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