Hydrochloric Acid → HCID 178428442, compound

HRID 1059980Notes

Reaction equation

HRID 1059980 reaction equation
C(OC([NH:8][C:9]([NH:25]C(OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[C:15]([C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=2)[CH:14]=[CH:13][C:12]=1[CH3:24])=O)(C)(C)C.[ClH:33]>ClCCl.O1CCOCC1>[ClH:33].[ClH:33].[CH3:24][C:12]1[CH:13]=[CH:14][C:15]([C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=2)=[CH:16][C:11]=1[NH:10][C:9]([NH2:25])=[NH:8]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 135710940N,N'-bis(tert-butoxycarbonyl)-N''-(2-methyl-5-(4-methylpyridin-2-yl)phenyl)guanidine

Product 1

HCID 178428442HCID 178428442, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(2-methyl-5-(4-methylpyridin-2-yl)phenyl)guanidine (200 mg) in dichloromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at room temperature for 16 hours. The solvent was evaporated under reduced pressure. To the residue were added ethanol (2 ml) and ethyl acetate (10 ml), and the precipitate was collected by filtration and dried under reduced pressure to give (2-methyl-5-(4-methylpyridin-2-yl)phenyl)guanidine dihydrochloride (127 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue were added ethanol (2 ml) and ethyl acetate (10 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-8c76f119f16741688f9b1dd671600e3f
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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