反应详情

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(2-fluoro-5-(4-methoxypyridin-2-yl)phenyl)guanidine (0.2 g) in dichloromethane (2 ml) was added a solution of hydrogen chloride in 1,4-dioxane (4N, 4 ml), and the mixture was stirred at room temperature for 24 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (100 ml), and the resultant precipitate was collected by filtration and dried under reduced pressure to give (2-fluoro-5-(4-methoxypyridin-2-yl)phenyl)guanidine dihydrochloride (143 mg).

1. customThe solvent was evaporated under reduced pressure
2. additionTo the residue was added 5% ethanol in ethyl acetate (100 ml)
3. filtrationthe resultant precipitate was collected by filtration
4. customdried under reduced pressure