反应详情

A suspension of 7-(4-methoxypyridin-2-yl)-2-quinolone (130 mg) in phosphorus oxychloride (5 ml) was refluxed for 2 hours. The mixture was evaporated under reduced pressure. The residue was poured into a saturated aqueous sodium hydrogencarbonate solution and extracted with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate and evaporated under reduced pressure to give 2-chloro-7-(4-methoxypyridin-2-yl)quinoline (140mg).

1. temperaturewas refluxed for 2 hours
2. customThe mixture was evaporated under reduced pressure
3. additionThe residue was poured into a saturated aqueous sodium hydrogencarbonate solution
4. extractionextracted with dichloromethane
5. washThe organic layer was washed with brine
6. dry with materialdried over sodium sulfate
7. customevaporated under reduced pressure