Hydrochloric Acid → HCID 18631027, compound

Participants

Reaction Steps

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(2-(1,3-dioxolan-2-yl)-5-(4-methylpyridin-2-yl)phenyl)guanidine (190 mg) in ethanol (2 ml) was added hydrochloric acid (36%, 1 ml), and the mixture was stirred for 6 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 2-amino-7-(4-methylpyridin-2-yl)quinazoline dihydrochloride (92 mg).

Provenance & Evidence