Hydrochloric Acid → HCID 18631027, compound

HRID 1060017Notes

Reaction equation

HRID 1060017 reaction equation
C(OC([NH:8][C:9]([NH:29][C:30](OC(C)(C)C)=O)=[N:10][C:11]1[CH:16]=[C:15]([C:17]2[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=2)[CH:14]=[CH:13][C:12]=1C1OCCO1)=O)(C)(C)C.[ClH:37]>C(O)C>[ClH:37].[ClH:37].[NH2:8][C:9]1[N:29]=[CH:30][C:12]2[C:11](=[CH:16][C:15]([C:17]3[CH:22]=[C:21]([CH3:23])[CH:20]=[CH:19][N:18]=3)=[CH:14][CH:13]=2)[N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 135710950HCID 135710950, compound

Product 1

HCID 18631027HCID 18631027, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(2-(1,3-dioxolan-2-yl)-5-(4-methylpyridin-2-yl)phenyl)guanidine (190 mg) in ethanol (2 ml) was added hydrochloric acid (36%, 1 ml), and the mixture was stirred for 6 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (50 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 2-amino-7-(4-methylpyridin-2-yl)quinazoline dihydrochloride (92 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionTo the residue was added 5% ethanol in ethyl acetate (50 ml)
  3. filtrationthe precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-42b35997d1a74097973c2f2680412bdb
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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