Water → HCID 18667621, compound

HRID 1060023Notes

Reaction equation

HRID 1060023 reaction equation
[CH2:1]([NH2:3])[CH3:2].F[C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][N:12]=2)=[CH:7][C:6]=1[N+:19]([O-:21])=[O:20].O>C(O)C>[CH2:1]([NH:3][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][N:12]=2)=[CH:7][C:6]=1[N+:19]([O-:21])=[O:20])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 18667517HCID 18667517, compound

Product 1

HCID 18667621HCID 18667621, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethylamine in ethanol (20% w/w, 2 ml) was added 1-fluoro-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (200 mg). The mixture was stirred at ambient temperature for 4 hours and poured into water. The precipitate was collected by filtration and dried to give 1-ethylamino-4-(4-methoxypyridin-2-yl)-2-nitrobenzene (206 mg).

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-356955781f86442a8db51ade840c7085
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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