反应详情

温度

60 °C

To a stirred solution of 2-amino-4-methoxy-benzothiazole (180 mg, 1 mol) in THF (5 ml) was added benzylisocyanate (166 mg, 1.25 mmol) and the mixture heated to 60° C. for 3 h. After evaporation of the solvent, ether (5 ml) was added and the suspension ultra-sonnicated for 10 min with addition of nHexane (5 ml). This suspension was filtered and washed further with ether/nHexane (1:1) to afford the title compound, after drying under vacuum, as a white solid (220 mg, 70% yield), MS: m/e=313 (M+).

1. customAfter evaporation of the solvent, ether (5 ml)
2. additionwas added
3. additionthe suspension ultra-sonnicated for 10 min with addition of nHexane (5 ml)
4. filtrationThis suspension was filtered
5. washwashed further with ether/nHexane (1:1)