Methyl 6-chloropyridine-3-carboxylate → 6-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzyloxy}-nicotinic acid methyl ester

HRID 106029Notes

Reaction equation

HRID 106029 reaction equation
[CH3:25][O:26][C:27]([c:28]1[cH:29][n:30][c:31]([Cl:34])[cH:32][cH:33]1)=[O:35].[Cl:1][c:2]1[c:3]([CH:10]([C:11]([C:12]([F:13])([F:14])[F:15])([OH:16])[c:17]2[cH:18][c:19]([Cl:23])[n:20][cH:21][cH:22]2)[CH3:24])[cH:4][cH:5][c:6]([CH2:8][OH:9])[cH:7]1>>[Cl:1][c:2]1[c:3]([CH:10]([C:11]([C:12]([F:13])([F:14])[F:15])([OH:16])[c:17]2[cH:18][c:19]([Cl:23])[n:20][cH:21][cH:22]2)[CH3:24])[cH:4][cH:5][c:6]([CH2:8][O:9][c:31]2[n:30][cH:29][c:28]([C:27]([O:26][CH3:25])=[O:35])[cH:33][cH:32]2)[cH:7]1

Participants

3

Reactant 2

HCID 254249Methyl 6-chloropyridine-3-carboxylateHCID 252544493-(2-Chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol

Product 1

HCID 723105776-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzyloxy}-nicotinic acid methyl ester

Sources & evidence

ORD record
ord-d4b038da3b2644269195821aae37839d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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